Luigi Notarangelo, MD

Director of Research and Molecular Diagnosis, Harvard Medical School

“Novel Cellular Platforms for Primary Immunodeficiency Disease Modeling”

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Age-related changes in immune cell composition and functionality are associated with multimorbidity and mortality. However,

Dysfunction of alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung alveoli, is

Individuals homozygous for the ‘‘Z’’ mutation in alpha-1 antitrypsin deficiency are known to be at

Summary A robust method of producing mature T cells from iPSCs is needed to realize


Location The Center for Regenerative Medicine 670 Albany St 2nd Floor Boston MA 02118 Boston University & Boston Medical Center