Why are some 100 plus-year-old men and women as cognitively alert and intact as peers thirty years younger? Why has Alzheimer’s disease (AD) not impacted them? Thomas Perls, MD, MPH, FACP, professor of medicine and Stacy Andersen PhD, assistant professor of medicine at Boston University School of Medicine (BUSM) and their colleagues seek to learn more about these centenarian cognitive super-agers, thanks to a $20 million grant from the National Institutes of Health’s National institute on Aging and the McKnight Foundation.

The latest publication from the Kotton lab detailing the transcriptomic programs of iPSC-derived alveolar cells
Dysfunction of alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung alveoli, is