Welcome to the CReM

Advancing science to heal the world.
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Mission & Vision

Advancing science to heal the world.

The Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center is a physically contiguous state-of-the-art facility housed in newly renovated expansive space located on the Boston University Medical Campus. The Center’s footprint consists of 10,000 sq ft of wet bench space and 6,000 sq ft of offices.

Open-source biology

In a nutshell, Open Source Biology refers to the sharing of reagents, ideas, databases and expertise without boundaries or exclusivity. This philosophy is at the center of our mission of ‘advancing science to heal the world’. All CReM research initiatives are thus pursued with our overarching mission in mind. In keeping with this purpose, we embrace an Open Source approach to scientific research, endorsing the free sharing of our published reagents without delays or constricting material transfer agreements (MTA).

Our most important protocols and vector sequences are also posted on our website for free download, as one illustration of our Open Source philosophy. We realize that at times our mission and philosophy is at odds with today’s focus on protecting intellectual property and the needs of institutions and industry. Thus, we have written a constitution, documenting principles that guide our decisions and approaches to collaborations.
We encourage fellow academic scientists to join us in our approach, and we hope that with time this approach will become the mainstream of academic medicine where discoveries and reagents are truly ‘for all mankind’.

The CReM’s Open Source Biology Approach: Guiding Principles

Principle 1

Reagents, tools, vectors, cell lines, and protocols generated by the CReM and requested by academic researchers or not-for-profit organizations will be shared by the CReM as quickly as possible.

Principle 2

When entering collaborations or sharing reagents, tools, vectors, or cell lines with industry partners, we will consider entering into MTA or other legal intellectual property agreements as we understand that the differing needs of industry partners requires them to have legal IP protection in place before proceeding with collaborations.

Principle 3

All human and animal research will only be conducted with institutional regulatory approval, such as IACUC and IRB oversight.

Principle 4

Published protocols, vector sequences, and bioinformatics databases (e.g. microarray files), will be either posted on our website for free download, posted on the national Gene Expression Omnibus (GEO) for free download, or shared free of charge by email request with academic and not for profit researchers.

CReM Labs

We are a dynamic group of investigators passionate about stem cells, developmental biology and regenerative medicine. Our members come from more than 15 different countries and get together to fulfill our mission: Advancing science to heal the world.

CReM Leadership

The Center for Regenerative Medicine (CReM) at Boston University’s Medical Campus is dedicated to advancing stem cell research and regenerative medicine for the sake of patients — particularly those suffering from diseases seen at Boston Medical Center, the teaching hospital of Boston University School of Medicine.


Darrell Kotton, MD
Professor of Medicine
Center for Regenerative Medicine (CReM)
Darrell Kotton


Gustavo Mostoslavsky, MD PhD
Associate Professor of Medicine
Gastroenterology Section
Co-Director, CReM


Greg Miller
Lab Manager
Gregory Miller
Gabrielle Cockerham, MPH candidate
Administrative Assistant
Gabrielle Cockerham
Meenakshi Lakshminarayanan, MBA
Administrative Director

Core Managers

Marianne James, PhD
iPSC Core Manager
Pushpinder Bawa, PhD
Bioinformatics Core Manager
Pushpinder Bawa

Make a monetary donation
to support our cell sharing mission.

If you want to support our mission, please click on the link below.