CReM Seminar Series

The Center for Regenerative Medicine Seminar Series features invited speakers presenting topics related to stem cell biology, developmental biology, gene therapy, tissue injury and repair, or regenerative medicine. All are welcome to attend, and no RSVP is needed. If you would like to be added to the CReM Seminar Series e-mail list, please direct your request to Gustavo Mostoslavsky.

Please contact the Seminar Series organizer, Dr. Gustavo Mostoslavsky gmostosl@bu.edu, with any other inquiries.

Featured Seminar

Vadim Gladyshev, PhD

Professor, Medicine, Harvard Medical School
Director of Redox Medicine, Medicine, Brigham And Women’s Hospital

April 23, 2024 9:00 am

EBRC X715 Seminar Room

Vadim Gladshev, PhD

Upcoming Seminars

Sara Prescott, PhD

Assistant Professor, MIT Department of Biology
Investigator, The Picower Institute for Learning & Memory
Massachusetts Institute of Technology
Cambridge, Massachusetts

June 11, 2024 9:00 am
EBRC X715 Seminar Room

Klaus Kaestner, PhD, MS

Thomas and Evelyn Suor Butterworth Professor in Genetics
Associate Director, Penn Diabetes Research Center

Smilow Center for Translational Research

University of Pennsylvania Perelman School of Medicine

Philadelphia, PA

October 8, 2024 9:00 am
EBRC X715 Seminar Room

Past Seminars (2009 – Present)

Olivier Pourquié, PhD

March 19, 2024 9:00 am

Samagya Banskota, PhD

March 12, 2024 9:00 am

Jenna Galloway, PhD

January 16, 2024 9:00 am

Pankaj Mehta, PhD

December 12, 2023 9:00 am

Mary Williams Lecture Series featuring Yohannes Tesfaigizi, PhD

November 15, 2023 3:30 pm

Trista North, PhD

November 7, 2023 9:00 am

Anita Kurmann Memorial Lecture Series featuring Jichao Chen, PhD, MHS

October 31, 2023 9:00 am

Su Ryon Shin, PhD

October 10, 2023 9:00 am

Lior Pachter, PhD

September 12, 2023 9:00 am

Alejandro Sánchez Alvarado, PhD

June 13, 2023 9:00 am

Muzlifah Haniffa, FMedSci

May 16, 2023 9:00 am

Matthias Stadtfeld, PhD

April 4, 2023 9:00 am

Effie Apostolou, PhD

March 21, 2023 9:00 am

Julia TCW, PhD

February 14, 2023 9:00 am

Christopher Chen, MD, PhD

January 10, 2023 9:00 am

Raul Mostoslavsky, MD, PhD

November 8, 2022 9:00 am

Mary Williams Lecture Series featuring Frances Eun-Hyung Lee, MD

October 26, 2022 3:30 pm

Anita Kurmann Memorial Lecture Series featuring Aaron Zorn, PhD

October 25, 2022 9:00 am

Yonatan Stelzer, PhD

October 11, 2022 9:00 am

Norbert Pardi, PhD

September 6, 2022 9:00 am

Kyle McCracken, MD, PhD

June 14, 2022 9:00 am

Mario Luca Suvà, MD, PhD

May 10, 2022 9:00 am

Lee Rubin, PhD

April 12, 2022 9:00 am

Matthias Hebrok, PhD

March 15, 2022 9:00 am

Jonathan Kropski, MD

February 8, 2022 9:00 am

Cynthia A. Bradham, PhD

January 11, 2021 9:00 am

Daniel Segrè, PhD

December 7, 2021 10:00 am

Hanna Mikkola, MD, PhD

November 9, 2021 9:00 am

Anita Kurmann Memorial Lecture featuring Mikael Nilsson, MD PhD

October 26, 2021 9:00 am

Christopher Sturgeon, PhD

October 5, 2021 9:00 am

Darrell Kotton, MD

September 7, 2021 9:00 am

Jacob Hanna, MD, PhD

June 8, 2021 9:00 am

Jose Polo, PhD

April 20, 2021 9:00 am

Angie Serrano, PhD

February 16, 2021 9:00 am

Heather McCauley, PhD

February 9, 2021 9:00 am

Lindsay LaFave, PhD

December 8, 2020 12:00 am

Anita Kurmann Memorial Lecture Series featuring Dr. Sabine Costagliola

November 18, 2020 9:00 am

Elliott Hagedorn, PhD

October 13, 2020 9:00 am

Jason Rock, PhD

June 16, 2020 9:00 am

Ella Zeldich, PhD

May 12, 2020 9:00 am

Satdarshan (Paul) Monga, MD

February 11, 2020 9:00 am

Emma Rawlins, PhD

January 7, 2020 9:00 am

Connie Cepko, PhD

December 10, 2019 9:00 am

Annita Kurmann Memorial Lecture featuring Maike Sander, MD

November 12, 2019 9:00 am

Samantha Morris, PhD

October 8, 2019 9:00 am

John Manis, MD

September 10, 2019 9:00 am

Jason Spence, PhD

June 4, 2019 9:00 am

Cynthia Dunbar, MD

May 7, 2019 9:00 am

Andrew Emili, PhD

April 9, 2019 9:00 am

Thorsten Schlaeger, PhD

March 12, 2019 9:00 am

Wolfram Goessling, MD, PhD

February 12, 2019 9:00 am

Jianwen Que, PhD

January 8, 2019 9:00 am

Christopher Lengner, PhD

December 11, 2018 9:00 am

Anita Kurmann Memorial Lecture featuring Xin Sun, PhD

November 6, 2018 9:00 am

Ruben Dries, PhD

October 16, 2018 9:00 am

Wilson Wong, PhD

September 18, 2018 9:00 am

Mary Williams Lecture featuring Donald McDonald, MD, PhD

June 12, 2018 9:00 am

Ophir Klein, PhD

May 8, 2018 9:00 am

Brigid Hogan, PhD

April 17, 2018 9:00 am

James Kiley, PhD

February 13, 2018 9:00 am

Paola Arlotta, PhD

January 16, 2018 9:00 am

Effie Apostolou, PhD

December 5, 2017 9:00 am

Kirsten Sadler, PhD

November 29, 2017 9:00 am

Ibrahim Ozbolat, PhD

November 7, 2017 9:00 am

Constantina Christodolou, PhD

October 3, 2017 9:00 am

Allon Klein, PhD

September 5, 2017 9:00 am

Xaralabos (Bob) Varelas, PhD

June 6, 2017 9:00 am

Melina Fan, PhD

May 9, 2017 9:00 am

Igor Slukvin, MD, PhD

February 7, 2017 9:00 am

Valentina Greco, PhD

January 10, 2017 9:00 am

Jay Rajagopal, MD

November 15, 2016 9:00 am

Ari Melnick, MD

October 18, 2016 9:00 am

Janet Rossant, PhD

September 27, 2016 9:00 am

David Scadden, MD

September 13, 2016 9:00 am

Wellington Cardoso, MD, PhD

June 14, 2016 9:00 am

Edward Morrisey, PhD

May 10, 2016 9:00 am

Rene Maehr, PhD

April 19, 2016 9:00 am

David T. Scadden, MD

February 16, 2016 9:00 am

Bruce Ksander, PhD

January 12, 2016 9:00 am

Jason Rock, PhD

December 8, 2015 9:00 am

Gordon Keller, PhD

November 10, 2015 9:00 am

Benjamin Ohlstein, PhD

October 13, 2015 9:00 am

Matthias Stadtfeld, PhD

September 22, 2015 9:00 am

John Shannon, PhD

July 14, 2015 9:00 am

Esteban O. Mazzoni, PhD

June 9, 2015 9:00 am

Vasan Ramachandran, MD

May 5, 2015 9:00 am

Stephen Wong, PhD

March 17, 2015 9:00 am

Maria Valeria Canto Soler, PhD

February 3, 2015 9:00 am

Valerie Gouon-Evans, PharmD, PhD

January 13, 2015 9:00 am

Harald Ott, MD

December 9, 2014 9:00 am

Michael Levin, PhD

November 4, 2014 9:00 am

Holger Willenbring, MD, PhD

October 14, 2014 9:00 am

Stephen Duncan, DPhil

September 9, 2014 9:00 am

Marius Wernig, MD, PhD

July 1, 2014 9:00 am

Christopher Chen, PhD

May 6, 2014 9:00 am

Charles Lin, PhD

April 8, 2014 9:00 am

Hans-Willem Snoeck, MD, PhD

March 18, 2014 9:00 am

Paul Gadue, PhD

February 11, 2014 9:00 am

Jacob Hanna, MD, PhD

January 7, 2014 9:00 am

Leonard I. Zon, MD

October 22, 2013 9:00 am

Alon Goren, PhD

November 6, 2013 9:00 am

Luigi Notarangelo, MD

June 4, 2013 9:00 am

Stuart Orkin, MD

April 30, 2013 9:00 am

Carla Kim, PhD

January 15, 2013 9:00 am

Konrad Hochedlinger, PhD

December 4, 2012 9:00 am

Joyce Y. Wong, PhD

October 16, 2012 9:00 am

Alan Cantor, MD, PhD

September 18, 2012 9:00 am

Justin Ichida, PhD

June 26, 2012 9:00 am

Amy Wagers, PhD

May 15, 2012 9:00 am

Alejandro B. Balazs, PhD

March 20, 2012 9:00 am

James M. Wells, PhD

February 28, 2012 9:00 am

Sangeeta Bhatia, MD, PhD

January 10, 2012 9:00 am

Richard Gregory, PhD

December 13, 2011 9:00 am

Juan Enriquez, BA, MBA

December 6, 2011 9:00 am

Fernando Camargo, PhD

November 15, 2011 9:00 am

Wellington V. Cardoso, MD, PhD

October 4, 2011 12:00 am

Hans-Willem Snoeck, MD, PhD

May 25, 2011 9:00 am

David T. Scadden, MD

May 3, 2011 9:00 am

Raul Mostoslavsky, MD, PhD

March 15, 2011 9:00 am

Helen M. Blau, PhD

February 15, 2011 9:00 am

J. Keith Joung, PhD

December 7, 2010 9:00 am

Darrell N. Kotton, MD

November 9, 2010 9:00 am

Eran Meshorer, PhD

October 5, 2010 9:00 am

Konrad Hochedlinger, PhD

September 21, 2010 9:00 am

Lou Gerstenfeld, PhD

May 25, 2010 9:00 am

Jonathan Frampton, PhD

April 29, 2010 4:00 pm

George Q. Daley, MD, PhD

March 16, 2010 9:00 am

Douglas A. Melton, PhD

January 19, 2010 9:00 am

Gary S. Stein, PhD

November 3, 2009 9:00 am

Chad Cowan, PhD

October 6, 2009 9:00 am

Rudolf Jaenisch, MD

September 15, 2009 9:00 am

George J. Murphy, PhD

June 9, 2009 9:00 am

Gustavo Mostoslavsky, MD, PhD

May 5, 2009 9:00 am

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Welcome to CReM

My name is Gabrielle. I'm the Administrative Assistant at CReM. Leave us a short message down below. We will get back to you ASAP!

The Wilson lab is focused on two major aspects of regenerative medicine:

1) Developing gene therapy approaches for the study and treatment of lung diseases: The ability to manipulate gene expression in specified lung cell populations has both experimental and therapeutic potential for lung disease. By developing viral vectors that transduce specific lung cell types in vivo, we hope to minimize potential off-target effects while maximizing our ability to target diseased cell populations. We work with lentiviral and AAV vectors to overexpress or knockdown expression of genes important to disease pathogenesis in the lung.

2) Utilizing induced pluripotent stem cells (iPSC) to study human lung and liver diseases: The Wilson lab is interested in the application of patient-derived iPS cells for the study of lung and liver diseases, such as alpha-1 antitrypsin deficiency (AATD).

The Hawkins Lab is interested in how the human lung develops and responds to injury to better understand human lung disease. Induced pluripotent stem cells (iPSCs) offer a unique opportunity to model human lung disease and bridge the gap between research in animal models and humans.

Using this iPSC platform, we are focused on understanding the molecular mechanisms that control human lung development. We hope to apply this knowledge to advance our understanding of and develop precision medicine approaches for lung disease.

The Murphy laboratory is composed of dynamic and passionate researchers who utilize multiple stem cell-based platforms to answer basic biological questions and combat disease. Central directions of the laboratory include: developmental hematopoiesis, the modeling of blood-borne disease, and discovery and therapeutic intervention in sickle cell disease, amyloidosis, and aging.

The Murphy Lab has pioneered: The world’s largest sickle cell disease-specific iPSC library and platforms and protocols that can used to recapitulate hematopoietic ontogeny and to develop and validate novel therapeutic strategies for the disease; The successful modeling of a protein folding disorder called familial amyloidosis demonstrating the ability to model a long-term, complex, multisystem disease in a relatively short time, using lineage-specified cells (hepatic, cardiac and neuronal) derived from patient-specific stem cells; The first iPSC library created from subjects with exceptional longevity (centenarians) that serves as an unlimited resource of biomaterials to fuel the study of aging and the development of novel therapeutics for aging-related disease.

www.murphylaboratory.com

@DRGJMurphy

The Serrano Lab studies neurodevelopment and cardiovascular development in the context of rare multi-systemic disorders originated by pathogenic variants in epigenetic modifiers like KMT2D.  

We aim to identify shared molecular and cellular mechanisms driving cardiovascular and brain development with particular interest in cell differentiation, migration, and cell cycle progression.  

Our lab combines rare disease modeling in zebrafish together with cardiovascular and neurobiology techniques and human iPSC-derived brain organoids and endothelial cells.  

We believe that a patient-forward focus to our projects will help us to get better understanding of disease mechanisms through basic science research. To this end, we are active in the collaborative community among field experts and rare disease patient-advocacy groups who drive our research program to identify therapeutic targets in patient-specific iPS cells. 

The Mostoslavsky Lab is a basic science laboratory in the Section of Gastroenterology in the Department of Medicine at Boston University.

Our goal is to advance our understanding of stem cell biology with a focus on their genetic manipulation via gene transfer and their potential use for stem cell-based therapy.

The Mostoslavsky’s Lab designed and constructed the STEMCCA vector for the generation of iPS cells, a tool that has become the industry standard for nuclear reprogramming. Project areas in the lab focuses on the use of different stem cell populations, including embryonic stem cells, induced Pluripotent Stem (iPS) cells, hematopoietic stem cells and intestinal stem cells and their genetic manipulation by lentiviral vectors.

Our laboratory have already established a large library of disease-specific iPS cells with a particular interest in utilizing iPS cells to model diseases of the liver, the gastrointestinal tract, prion-mediated neurodegenerative diseases and immune-based inflammatory conditions, using iPSC-derived microglia, macrophages and T/NK cells.

The Gouon-Evans lab investigates cellular and molecular mechanisms driving liver development, regeneration and cancer. We specifically interrogate the role of progenitor/stem cells and how they share similar molecular signature and functions during these 3 processes.

Our innovative tools include: 1) directed differentiation of human pluripotent stem cells (PSC) to generate in vitro liver progenitors and their derivative hepatocytes, the main functional cell type of the liver, 2) mouse models with lineage tracing strategy to track in vivo the fate of progenitor cells, 3) PSC derivative cell transplantation into mouse models with damaged livers as cell therapy for liver diseases, 3) dissection of liver cancer specimens from patients to identify and define the impact of specific cancer stem cells in liver oncogenesis.

Projects in the Gouon-Evans lab will lead to a better understanding of the liver development, to the establishment of multi-modular approaches for improving liver regeneration with PSC derivatives, and will reveal the impact of specific cancer stem cells as a target for diagnosis and therapy in liver oncogenesis.