Positions Available

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Opportunity: A postdoctoral fellow position is available immediately in the Wilson laboratory at the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical. We are seeking recent PhD candidates with research interests in human ESC/iPSC differentiation and disease modelling. Candidates enthusiastic about understanding the genetic and epigenetic basis of obstructive lung disease with a focus on lung epithelium are particularly encouraged to apply.

Duties and Responsibilities: Qualified candidates will work in a tight-knit research group with scientists at various training levels focusing on diverse projects related to stem cell and developmental biology.

Basic Qualifications: Applicants must have a Ph.D. in biological science or closely related field and relevant laboratory experience, including familiarity with tissue culture techniques. Successful candidates will be dedicated, creative, self-motivated critical thinkers with strong written and verbal communication skills.

Additional Qualifications: Ph.D or M.D. in biological science or a related field is required. The successful candidate should be able to manage multiple detail-oriented tasks with minimal supervision, capable of trouble-shooting and critical thinking, self-motivated, dedicated and creative.

Contact: Please forward contact details and a current CV/resume to Dr. Andrew Wilson at awilson@bu.edu
More information: https://sites.bu.edu/wilsonlab

Opportunity: A position as a postdoctoral fellow is immediately available in the laboratory of Gustavo Mostoslavsky, M.D., PhD at Boston University/Boston Medical Center at the Center for Regenerative Medicine (CReM). The position is in the field of stem cell biology, iPSC and differentiation towards T/NK cell lineages, and is a great opportunity for a motivated individual interested in gaining experience, technical expertise and a publication record for a career in cutting edge research.

Duties and Responsibilities: Highly motivated, successful candidates will implement and coordinate ongoing research projects as well as design and direct novel strategies utilizing iPSC modeling of T cell specification. Applicants with technical expertise related to iPSC biology, gene editing and T cell development are preferred. Familiarity with procedures including but not restricted to plasmid and genomic DNA isolation, cloning, cell culture, PCR, blotting, various tissue culture procedures, and molecular biology techniques would be helpful. Candidate will also be required to work independently as well as part of a team.

Basic Qualifications: Relevant laboratory experience; especially familiarity with molecular biology, biochemistry, and tissue culture techniques is necessary.

Additional Qualifications: Ph.D or M.D. in biological science or a related field is required. The successful candidate should be able to manage multiple detail-oriented tasks with minimal supervision, capable of trouble-shooting and critical thinking, self-motivated, dedicated and creative.

Contact:  Please forward contact details and a current CV/resume to Dr. Gustavo Mostoslavsky at gmostosl@bu.edu

More information: www.mostoslavskylab.com

Opportunity: Are you a gene editor who wants to focus on editing stem cells in a warm, welcoming environment filled with collaborative teammates? Come join us in the Kotton Lab at the Center for Regenerative Medicine (CReM) as we pursue our mission of editing iPSCs for lung disease modeling and future therapies. This staff scientist will join an interdisciplinary team working with induced pluripotent stem cells (iPSCs) – a great opportunity to further develop technical and team building skills, and a chance to share your talents with the world as we share your edited cells with the global research community.

Duties and Responsibilities: Successful candidates will work independently, and as part of a team focused on designing and deploying gene editing technologies (e.g. CRISPR-Cas9) to edit the human or mouse genome in pluripotent stem cells in culture.  Applicants with technical expertise related to molecular biology, plasmid cloning, and cell culture are preferred. The CReM and Boston University welcome applicants from diverse backgrounds!

Basic Qualifications: Applicants must have a Ph.D. in a biological science (or closely related field) and relevant laboratory experience, including familiarity with molecular biology and tissue culture techniques.

Contact:  Please forward contact details and a current CV/resume to mnarayan@bu.edu

More information: www.bumc.bu.edu/kottonlab

Opportunity: The iPSC Core at the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center is currently seeking a full-time Research Technician to join our team. The position is a great opportunity for a motivated individual interested in gaining experience and technical expertise in an exciting research field.

Duties and Responsibilities: The candidate will work closely with the manager of the iPSC Core on the generation of induced pluripotent stem cell (iPSC) lines and the maintenance of cell repository. Primary responsibilities will include quality assurance and characterization of iPSCs using techniques such as nucleic acid isolation, PCR, cDNA preparation, Real-time PCR and immunostaining. He/she will also assist with the creation of various genetically modified iPSC lines using genome-editing technologies (CRISPR/Cas9) for the study of developmental biology and disease modeling.

Basic Qualifications: Bachelor's degree in Biology or a related field is required. At least one year of cell culture experience with excellent sterile technique is essential. Background in molecular biology and familiarity with routine laboratory tasks are highly desirable.

Additional Qualifications: The successful candidate will be a motivated person with careful attention to detail, excellent organization and documentation skills.

Contact: Please send contact details and resume to Marianne James, Ph.D. at mfjames@bu.edu

Postdoctoral Fellow position Available in the Gouon-Evans Lab:

Opportunity: A postdoctoral fellow position is available September 1st 2022 at the Center for Regenerative Medicine (CReM) of Boston University/Boston Medical Center. The position is in the field of liver regeneration using the iPSC system and liver deficiency mouse models. Projects will investigate specific aspects of liver regeneration with application of nucleoside-modified mRNA complexed to lipid nanoparticles to treat liver diseases (Nature Communication, 2021, Bioprotocols, 2021). These projects may include (1) hiPSC-based cell transplantation strategies to repopulate diseased liver mouse models, (2) in vivo gene editing of mutated alpha1 antitrypsin (AAT) gene to rescue the liver in an AAT liver disease mouse model, (3) and understanding sexually dimorphic liver injury due to acetaminophen intoxication to identify novel therapeutic intervention.

Expected qualifications: Ph.D. in biological science or a related field. We are looking for highly motivated candidates with strong background in pluripotent stem cell biology or developmental/regenerative biology in mice or both. The laboratory expects that the fellows will be outstanding for enthusiasm, appreciation and capability for diligent and hard work, ingenuity, profound curiosity and creativity, extensive knowledge and technical skills, and proficiency in writing and data exploration and visualization.

Contact: Applicants should submit current CV/resume with two/three references to Dr. Valerie Gouon-Evans at valerige@bu.edu

Information about the Gouon-Evans Lab can be found at: https://sites.bu.edu/gouonevanslab

Postdoctoral Fellow position Available in the Serrano Lab:

Opportunity: The Serrano Lab is seeking a creative, thoughtful, and motivated postdoctoral fellow to join the lab at the Center for Regenerative Medicine (CReM), Boston University. The position is at the intersection of cardiovascular and neurodevelopmental research using zebrafish and human iPSC-derived models.
The Serrano Lab is a young yet promising lab that offers career development opportunities and strong mentorship in a thriving scientific community. As a postdoctoral fellow, you will be supported to pursue your own career goals in academia and/or industry while receiving guidance and mentorship from your PI, a mentoring committee, peers, and the incredibly collaborative community at the CReM and BUMC.

Duties and Responsibilities: Qualified candidates will lead an established research project as well as develop their own projects in the context of our research interests. Successful candidates will work in a highly collaborative group and are expected to actively mentor scientists at several training levels.

Qualifications:
Ph.D. or M.D. in biological science or a related field is required. Applicants should have demonstrated expertise in at least 3 of the following areas:

  • pluripotent stem cell biology,
  • developmental biology in zebrafish,
  • tissue culture techniques,
  • gene editing,
  • zebrafish transgenic generation,
  • zebrafish cell transplantation assays,
  • super-resolution imaging acquisition and analysis,
  • bioinformatics and biostatistics

We welcome applicants from diverse backgrounds!

Contact: To apply, please forward a cover letter and a current CV/resume to Angie Serrano at maserr@bu.edu. In the body of the email, please state in three sentences why you would like to join our lab.More information:
www.theserranolab.com
www.crem.bu.edu/research-at-crem/

Opportunity: The Vanuytsel Lab is seeking a curious, thoughtful and motivated laboratory technician/manager to join the lab at the Center for Regenerative Medicine (CReM), Boston University. The Vanuytsel Lab is a young lab, embedded in a thriving scientific community adhering to principles of collegiality, collaboration and open source biology. We offer exciting research, a strong focus on mentorship and ample career development opportunities.

The Lab: The Vanuytsel lab’s mission is to find better solutions for patients suffering from blood disorders. To do so, we 1) study hematopoietic development and the biology of blood stem cells to improve hematopoietic stem cell transplantation outcomes and we 2) generate red blood cells from sickle cell disease patient-specific induced pluripotent stem cells (iPSCs) to assess novel therapeutic options across the diverse patient population that we serve here at the Center of Excellence in Sickle Cell Disease at Boston Medical Center.

Responsibilities: The role involves managing day-to-day operations of the lab, performing experiments and reporting results. Besides gaining organizational, managerial and research experience, you will have a unique opportunity to be involved in all aspects of starting up a lab within an existing state-of-the art infrastructure.

Specific duties will involve:

  • Cell culture: iPSC maintenance, expansion and routine mycoplasma testing
  • Differentiation of iPSCs to red blood cells
  • Process blood products and isolate CD34+ cells for downstream treatment and analysis
  • Flow cytometric assessment of cells
  • Transplantation assays in immunocompromised mice to assess the functionality of human hematopoietic stem cells
  • Spatial transcriptomics: sample preparation, optimizing workflow,..
  • Perform standard molecular biology techniques such as qRT-PCR, Western blot, immunofluorescence (IF)
  • Plan, assist and conduct research, including collection and recording of results and samples
  • Data analysis, presentation and report preparation
  • Help set up and maintain an efficiently operating lab (ordering, keeping logs and inventories up to date)
  • Actively contribute to a welcoming and supportive lab environment

Required qualifications:

  • Bachelor’s degree in Biology or a related field
  • Demonstrated record of accomplishment, assisting, initiating and/or completing a research project (poster presentation, scientific communication, publication,..)
  • Organization skills, ability to work well with others, honesty and attention to detail are key

An excellent candidate will exhibit the following:

  • Experience with cell culture and/or working with mice
  • Experience with flow cytometry
  • Bioinformatics knowledge, computational skills

Contact: Please forward a cover letter and a current CV/resume to Gabrielle Cockerham at gabbyac@bu.edu

This position is a great opportunity for a motivated individual interested in gaining experience and technical expertise in an exciting research field within Kotton Laboratory in the Center for Regenerative Medicine (CReM) and Boston University School of Medicine.

Duties will include conducting supervised bench-top experiments on stem cell lines, performing gene therapy techniques, and carrying out basic lab manager duties. Your time will primarily be spent performing experiments and you will work as part of a highly motivated, fun, and successful team in an outstanding environment! A 2-year commitment is expected.

Duties and Responsibilities: The candidate will work closely with lab members to support the different research projects. The majority of techniques involve cell culture of mouse and human stem cell lines (such as iPS cells) as well as work with laboratory mice. Specifically, this will include cell culture for maintenance and expansion, basic characterization using PCR, cDNA preparation, Real-time PCR and immunostaining. He/she may also assist with the creation of various genetically modified iPSC lines using genome-editing technologies for the study of developmental biology and disease modeling. In addition, he/she will be in charge of ordering and purchasing and maintaining the lab stocks. Organization skills, ability to work well with others, and willingness to learn lab techniques are key.

Qualifications: Bachelor's degree in Biology or a related field is required. Cell culture experience is desired but not required. Background in molecular biology and familiarity with routine laboratory tasks are highly desirable. The successful candidate will be a motivated person with careful attention to detail, excellent organization and documentation skills.

Learn more about the Kotton Lab and the CReM at http://www.bumc.bu.edu/kottonlab/.

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