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Opportunity: A postdoctoral fellow position is available immediately in the Wilson laboratory at the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical. We are seeking recent PhD candidates with research interests in human ESC/iPSC differentiation and disease modelling. Candidates enthusiastic about understanding the genetic and epigenetic basis of obstructive lung disease with a focus on lung epithelium are particularly encouraged to apply.

Duties and Responsibilities: Qualified candidates will work in a tight-knit research group with scientists at various training levels focusing on diverse projects related to stem cell and developmental biology.

Basic Qualifications: Applicants must have a Ph.D. in biological science or closely related field and relevant laboratory experience, including familiarity with tissue culture techniques. Successful candidates will be dedicated, creative, self-motivated critical thinkers with strong written and verbal communication skills.

Additional Qualifications: Ph.D or M.D. in biological science or a related field is required. The successful candidate should be able to manage multiple detail-oriented tasks with minimal supervision, capable of trouble-shooting and critical thinking, self-motivated, dedicated and creative.

Contact: Please forward contact details and a current CV/resume to Dr. Andrew Wilson at awilson@bu.edu
More information: https://sites.bu.edu/wilsonlab

Postdoctoral Fellow position Available in the Gouon-Evans Lab:

Opportunity: A postdoctoral fellow position is available September 1st 2022 at the Center for Regenerative Medicine (CReM) of Boston University/Boston Medical Center. The position is in the field of liver regeneration using the iPSC system and liver deficiency mouse models. Projects will investigate specific aspects of liver regeneration with application of nucleoside-modified mRNA complexed to lipid nanoparticles to treat liver diseases (Nature Communication, 2021, Bioprotocols, 2021). These projects may include (1) hiPSC-based cell transplantation strategies to repopulate diseased liver mouse models, (2) in vivo gene editing of mutated alpha1 antitrypsin (AAT) gene to rescue the liver in an AAT liver disease mouse model, (3) and understanding sexually dimorphic liver injury due to acetaminophen intoxication to identify novel therapeutic intervention.

Expected qualifications: Ph.D. in biological science or a related field. We are looking for highly motivated candidates with strong background in pluripotent stem cell biology or developmental/regenerative biology in mice or both. The laboratory expects that the fellows will be outstanding for enthusiasm, appreciation and capability for diligent and hard work, ingenuity, profound curiosity and creativity, extensive knowledge and technical skills, and proficiency in writing and data exploration and visualization.

Contact: Applicants should submit current CV/resume with two/three references to Dr. Valerie Gouon-Evans at valerige@bu.edu

Information about the Gouon-Evans Lab can be found at: https://sites.bu.edu/gouonevanslab

Postdoctoral Fellow position Available in the Serrano Lab:

Opportunity: The Serrano Lab is seeking a creative, thoughtful, and motivated postdoctoral fellow to join the lab at the Center for Regenerative Medicine (CReM), Boston University. The position is at the intersection of cardiovascular and neurodevelopmental research using zebrafish and human iPSC-derived models.
The Serrano Lab is a young yet promising lab that offers career development opportunities and strong mentorship in a thriving scientific community. As a postdoctoral fellow, you will be supported to pursue your own career goals in academia and/or industry while receiving guidance and mentorship from your PI, a mentoring committee, peers, and the incredibly collaborative community at the CReM and BUMC.

Duties and Responsibilities: Qualified candidates will lead an established research project as well as develop their own projects in the context of our research interests. Successful candidates will work in a highly collaborative group and are expected to actively mentor scientists at several training levels.

Qualifications:
Ph.D. or M.D. in biological science or a related field is required. Applicants should have demonstrated expertise in at least 3 of the following areas:

  • pluripotent stem cell biology,
  • developmental biology in zebrafish,
  • tissue culture techniques,
  • gene editing,
  • zebrafish transgenic generation,
  • zebrafish cell transplantation assays,
  • super-resolution imaging acquisition and analysis,
  • bioinformatics and biostatistics

We welcome applicants from diverse backgrounds!

Contact: To apply, please forward a cover letter and a current CV/resume to Angie Serrano at maserr@bu.edu. In the body of the email, please state in three sentences why you would like to join our lab.More information:
www.theserranolab.com
www.crem.bu.edu/research-at-crem/

Opportunity: A postdoctoral fellow position is available immediately in the Hawkins laboratory at the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical. We are seeking recent PhD candidates with research interests in human ESC/iPSC differentiation and disease modelling. Candidates enthusiastic about understanding the genetic and epigenetic basis of obstructive lung disease with a focus on lung epithelium are particularly encouraged to apply.

Duties and Responsibilities: Qualified candidates will work in a tight-knit research group with scientists at various training levels focusing on diverse projects related to stem cell and developmental biology.

Basic Qualifications: Applicants must have a Ph.D. in biological science or closely related field and relevant laboratory experience, including familiarity with tissue culture techniques. Successful candidates will be dedicated, creative, self-motivated critical thinkers with strong written and verbal communication skills.

Additional Qualifications: Ph.D or M.D. in biological science or a related field is required. The successful candidate should be able to manage multiple detail-oriented tasks with minimal supervision, capable of trouble-shooting and critical thinking, self-motivated, dedicated and creative.

Contact: Please forward contact details and a current CV/resume to Dr. Finn Hawkins at hawk@bu.edu

More information: https://www.hawkins-lab.org/

Opportunity: A postdoctoral fellow position is available immediately in the Alysandratos Laboratory at the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center. We are seeking a highly motivated recent PhD graduate with research interests in human ESC/iPSC differentiation, stem cell biology, and disease modeling. Candidates enthusiastic about understanding the genetic and epigenetic basis of interstitial lung disease, with a particular focus on the lung epithelium, are especially encouraged to apply.

Duties and Responsibilities: The successful candidate will join a collaborative and supportive research environment and work closely with scientists at various training levels on projects related to stem cell biology, lung development, and pulmonary fibrosis. The candidate will be expected to design and execute experiments, analyze data, present findings, and contribute to manuscript and grant preparation.

Basic Qualifications: Applicants must hold a PhD or equivalent doctoral degree in a biological science or a closely related field. Prior laboratory experience and familiarity with tissue culture techniques are required.

Preferred Qualifications: Experience with stem cell culture, iPSC differentiation, molecular biology, genomics, single-cell technologies, bioinformatics, or pulmonary biology is desirable but not required. Successful candidates will be creative, self-motivated, and collaborative scientists with strong critical-thinking, organizational, and communication skills.

Contact: Please forward contact details and a current CV/resume to Dr. Kostas Alysandratos at kalysa@bu.edu

More information: https://sites.bu.edu/alysandratoslab/

Opportunity: This position is a great opportunity for a motivated individual interested in gaining experience and technical expertise in an exciting research field within the Kotton/Alysandratos Laboratories in the Center for Regenerative Medicine (CReM) and Boston University School of Medicine.

Duties and Responsibilities: Duties will include conducting supervised bench-top experiments on stem cell lines, performing gene therapy techniques, and carrying out basic lab manager duties. Your time will primarily be spent performing experiments and you will work as part of a highly motivated, fun, and successful team in an outstanding environment! A 2 year commitment is expected.

The candidate will work closely with lab members to support the different research projects. The majority of techniques involve cell culture of mouse and human stem cell lines (such as iPS cells). Specifically, this will include cell culture for maintenance and expansion, directed differentiation of iPSCs, basic characterization using PCR, cDNA preparation, Real-time PCR and immunostaining. He/she may also assist with the creation of various genetically modified iPSC lines using genome-editing technologies for the study of developmental biology and disease modeling. In addition, he/she will be in charge of ordering and purchasing and maintaining the lab stocks. Organization skills, ability to work well with others, and willingness to learn lab techniques are key.

Qualifications: Bachelor's degree in Biology or a related field is required. Background in molecular biology and familiarity with routine laboratory tasks and cell culture techniques are highly desirable. The successful candidate will be a motivated person with careful attention to detail, excellent organization and documentation skills.

Contact: Please forward contact details and a current CV/resume to Dr. Andrea Alber at aalber@bu.edu

More information: Learn more about the Kotton Lab, the Alysandratos Lab, and the CReM at http://www.bu.edu/dbin/stemcells/, http://www.bumc.bu.edu/kottonlab/, and https://sites.bu.edu/alysandratoslab/.

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The Alysandratos Lab’s mission is to advance our understanding of the inception of pulmonary fibrosis and identify druggable targets, with a specific focus on the alveolar epithelium. We believe that the poorly understood pathogenesis of pulmonary fibrosis, in part due to the lack of reliable human disease models, has been a major hurdle in developing effective therapies. To tackle this, we use patient-derived pluripotent stem cells (PSCs) to study the role of alveolar epithelial cells in initiating and perpetuating the fibrotic cascade with a goal of developing effective mechanistic therapies.

The Alysandratos Lab has openings for postdoctoral fellows – highly qualified applicants are encouraged to contact Dr. Alysandratos at kalysa@bu.edu for more information.

The Vanuytsel Lab’s mission is to find better solutions for patients suffering from blood disorders.

To accomplish this, we (1) generate red blood cells from sickle cell disease patient-specific induced pluripotent stem cells (iPSCs) to assess novel therapeutic options across the diverse patient population served here at Boston Medical Center; and (2) study hematopoietic development and the biology of blood stem cells to improve hematopoietic stem cell transplantation outcomes.

Here, our focus is on enhancing stem cell functionality rather than pure expansion of HSCs and we combine multi-parameter spectral flow cytometry, single cell omics and xenotransplantation assays to understand how expression profiles intersect with stem cell function. We also use these tools to map the subtle differences in hematopoietic stem cells throughout development, across mobilization regimens, and in the context of sickle cell disease.

The Wilson lab is focused on two major aspects of regenerative medicine:

1) Developing gene therapy approaches for the study and treatment of lung diseases: The ability to manipulate gene expression in specified lung cell populations has both experimental and therapeutic potential for lung disease. By developing viral vectors that transduce specific lung cell types in vivo, we hope to minimize potential off-target effects while maximizing our ability to target diseased cell populations. We work with lentiviral and AAV vectors to overexpress or knockdown expression of genes important to disease pathogenesis in the lung.

2) Utilizing induced pluripotent stem cells (iPSC) to study human lung and liver diseases: The Wilson lab is interested in the application of patient-derived iPS cells for the study of lung and liver diseases, such as alpha-1 antitrypsin deficiency (AATD).

The Hawkins Lab is interested in how the human lung develops and responds to injury to better understand human lung disease. Induced pluripotent stem cells (iPSCs) offer a unique opportunity to model human lung disease and bridge the gap between research in animal models and humans.

Using this iPSC platform, we are focused on understanding the molecular mechanisms that control human lung development. We hope to apply this knowledge to advance our understanding of and develop precision medicine approaches for lung disease.

The Murphy laboratory is composed of dynamic and passionate researchers who utilize multiple stem cell-based platforms to answer basic biological questions and combat disease. Central directions of the laboratory include: developmental hematopoiesis, the modeling of blood-borne disease, and discovery and therapeutic intervention in sickle cell disease, amyloidosis, and aging.

The Murphy Lab has pioneered: The world’s largest sickle cell disease-specific iPSC library and platforms and protocols that can used to recapitulate hematopoietic ontogeny and to develop and validate novel therapeutic strategies for the disease; The successful modeling of a protein folding disorder called familial amyloidosis demonstrating the ability to model a long-term, complex, multisystem disease in a relatively short time, using lineage-specified cells (hepatic, cardiac and neuronal) derived from patient-specific stem cells; The first iPSC library created from subjects with exceptional longevity (centenarians) that serves as an unlimited resource of biomaterials to fuel the study of aging and the development of novel therapeutics for aging-related disease.

www.murphylaboratory.com

@DRGJMurphy

The Serrano Lab studies neurodevelopment and cardiovascular development in the context of rare multi-systemic disorders originated by pathogenic variants in epigenetic modifiers like KMT2D.  

We aim to identify shared molecular and cellular mechanisms driving cardiovascular and brain development with particular interest in cell differentiation, migration, and cell cycle progression.  

Our lab combines rare disease modeling in zebrafish together with cardiovascular and neurobiology techniques and human iPSC-derived brain organoids and endothelial cells.  

We believe that a patient-forward focus to our projects will help us to get better understanding of disease mechanisms through basic science research. To this end, we are active in the collaborative community among field experts and rare disease patient-advocacy groups who drive our research program to identify therapeutic targets in patient-specific iPS cells. 

The Mostoslavsky Lab is a basic science laboratory in the Section of Gastroenterology in the Department of Medicine at Boston University.

Our goal is to advance our understanding of stem cell biology with a focus on their genetic manipulation via gene transfer and their potential use for stem cell-based therapy.

The Mostoslavsky’s Lab designed and constructed the STEMCCA vector for the generation of iPS cells, a tool that has become the industry standard for nuclear reprogramming. Project areas in the lab focuses on the use of different stem cell populations, including embryonic stem cells, induced Pluripotent Stem (iPS) cells, hematopoietic stem cells and intestinal stem cells and their genetic manipulation by lentiviral vectors.

Our laboratory have already established a large library of disease-specific iPS cells with a particular interest in utilizing iPS cells to model diseases of the liver, the gastrointestinal tract, prion-mediated neurodegenerative diseases and immune-based inflammatory conditions, using iPSC-derived microglia, macrophages and T/NK cells.

The Gouon-Evans lab investigates cellular and molecular mechanisms driving liver development, regeneration and cancer. We specifically interrogate the role of progenitor/stem cells and how they share similar molecular signature and functions during these 3 processes.

Our innovative tools include: 1) directed differentiation of human pluripotent stem cells (PSC) to generate in vitro liver progenitors and their derivative hepatocytes, the main functional cell type of the liver, 2) mouse models with lineage tracing strategy to track in vivo the fate of progenitor cells, 3) PSC derivative cell transplantation into mouse models with damaged livers as cell therapy for liver diseases, 3) dissection of liver cancer specimens from patients to identify and define the impact of specific cancer stem cells in liver oncogenesis.

Projects in the Gouon-Evans lab will lead to a better understanding of the liver development, to the establishment of multi-modular approaches for improving liver regeneration with PSC derivatives, and will reveal the impact of specific cancer stem cells as a target for diagnosis and therapy in liver oncogenesis.

Our research focuses on understanding how lung epithelial progenitors interact with their supportive niche in the contexts of pulmonary disease and repair. We use cell culture, mouse models, and cell engraftment to study and augment these interactions with the ultimate goal of establishing novel therapies for pulmonary disease.

In addition, it is our mission to foster a welcoming and supportive environment, both within our lab and the wider research community, in order to train the next generation of scientists. We strongly believe that a diverse and collaborative community is an essential foundation for exploring the world around us and developing effective treatments for patients.